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Sunday, May 19, 2019

Poisonous or Venomous?

Poison Ivy
Often used interchangeably when describing some plants and animals, in reality poisonous and venomous mean two different things.  Poisonous describes plants or animals that are harmful when consumed or touched.  Venomous refers to animals that inject venom into their prey, by means of a bite or sting, when hunting or for self-defense.  To add to the confusion, all venoms are a poison but not all poisons are venoms!

Poisonous species typically produce a toxin that can range from irritant to fatal. Plants such as Poison Ivy (Toxicodendron radicans) and some members of the Spurge family are considered irritants when they come in contact with skin, but this effect is produced through different mechanisms.  Nearly all parts of the Poison Ivy plant contain urushiol, which is a substance that gives us contact dermatitis, or a severely itchy and painful inflammation of the skin.  

Texas Bull Nettle
Spurges such as Texas Bull Nettle (Cnidoscolus texanus) and Betonyleaf Noseburn (Tragia betonicifolia) have raised structures called trichomes that are capable of ’stinging' animals and humans that brush against them.  These plants have trichomes on their leaves and stems that have bulbous tips that break off and reveal needle-like tubes that pierce the skin. They can cause an itching, burning rash by emitting onto the skin a mix of acetylcholine, formic acid, histamine, and serotonin.  

Jimsonweed or Sacred Datura
One local native plant, Jimsonweed or Sacred Datura (Datura wrightii) goes well beyond irritant to hallucinogenic and even fatal if ingested.  All parts of this plant contain toxic alkaloids, and the narcotic properties of this plant have been known by humans since before recorded history.  They once figured prominently in important religious ceremonies of various southwestern Native American tribes.

Gulf Coast Toad
Animals that are poisonous include most amphibians (frogs, toads, salamanders, and newts), that have some amount of toxins on their skin and within other tissues. Special skin glands produce useful proteins, some for use in respiration, others for fighting bacterial or fungal infections, and at least one in each species that is used for defense.  For example, many toad species will release their toxins when they feel threatened, such as when they are caught by a dog or cat, and can trigger drooling, vomiting, and respiratory or cardiac problems.

Western Diamondback Rattlesnake
While some snakes are the most commonly known venomous animals, all spiders, some lizards, and many bees, ants and wasps are venomous as well.  The venoms they inject through a bite or sting contain various classes of toxins designed to perform specific biological effects such necrosis or death in multiple cells (necrotoxins) or individual cells (cytotoxins), disruption of the nervous system (neurotoxins), or damage to muscle tissue (myotoxins).   The venom of our Western Diamondback Rattlesnake (Crotalus atrox) carries both necrotoxins and myotoxins, Black Widow spiders (Latrodectus macrons) carry both neurotoxins and cytotoxins, and Striped Bark Scorpions (Centruroides vittatus) and Texas Redheaded Centipedes (Scolopendra heros) carry neurotoxins.

Striped Bark Scorpion
Texas Redheaded Centipede
While the vast majority of snake toxins are transferred by bite, one exception includes garter snakes (Thamnophis sp.), which are small and harmless in terms of their bite but are toxic to eat because their bodies absorb and store the toxins of their amphibious prey.  In our area, these snakes include the Black-necked Garter Snake (T. cyrtopsis) and the Western Ribbon Snake (T. proximus).

Western Ribbon Snake
It is important to keep in mind that many plants and animals that are poisonous or venomous are not necessarily a guaranteed threat to humans, as much depends on how the plant or animal is encountered, its toxicity level, and the amount of toxin absorbed.  Regardless, respecting these species and giving them their space is the cardinal rule.  Interestingly, the medicinal use of venoms for therapeutic benefit in treating diseases dates back to 380 B.C. in ancient Greece.  Today, the venoms produced by different organisms, which contain hundreds of different bioactive elements, are isolated, purified, and screened, then studied to identify components that may have desirable therapeutic properties.  This research is often the starting point for developing a therapeutic drug, and those types of drugs on the market today are used to lower high blood pressure, relieve severe pain, act as blood thinners, treat Type 2 diabetes, and stop bleeding during surgical procedures.